A new study suggests depressed patients appear to exhaust the brain areas related to positive emotions.

The investigation challenges prior thought that individuals with depression have less brain activity in areas associated with positive emotion.

Instead, the new data suggest similar initial levels of activity, but an inability to sustain them over time.

The new work is reported online this week in the Proceedings of the National Academy of Sciences.

“Anhedonia, the inability to experience pleasure in things normally rewarding, is a cardinal symptom of depression,” explains University of Wisconsin-Madison graduate student Aaron Heller, who led the project.

“Scientists have generally thought that anhedonia is associated with a general reduction of activity in brain areas thought to be important for positive emotion and reward. In fact, we found that depressed patients showed normal levels of activity early on in the experiment.

“However, towards the end of the experiment, those levels of activity dropped off precipitously.

“Those depressed subjects who were better able to sustain activity in brain regions related to positive emotion and reward also reported higher levels of positive emotion in their everyday experience,” Heller continues.

“Being able to sustain and even enhance one’s own positive emotional experience is a critical component of health and well-being,” notes the study’s senior author, Richard Davidson.

“These findings may lead to therapeutic interventions that enable depressed individuals to better sustain positive emotion in their daily lives.”

During the study, 27 depressed patients and 19 control participants were presented with visual images intended to evoke either a positive or a negative emotional response. While viewing these images, participants were instructed to use cognitive strategies to increase, decrease or maintain their emotional responses to the images by imagining themselves in similar scenarios.

Heller and colleagues used functional magnetic resonance imaging (fMRI) to measure brain activity in the target areas. The scientists examined the extent to which activation in the brain’s reward centers to positive pictures was sustained over time.

Source: University of Wisconsin-Madison